Publications

@article{Choobdar265553b,
title = {Assessment of network module identification across complex diseases},
author = {Sarvenaz Choobdar and Mehmet E Ahsen and Jake Crawford and Mattia Tomasoni and Tao Fang and David Lamparter and Junyuan Lin and Benjamin Hescott and Xiaozhe Hu and Johnathan Mercer and Ted Natoli and Rajiv Narayan and and Aravind Subramanian and Jitao D Zhang and Gustavo Stolovitzky and Zoltán Kutalik and Kasper Lage and Donna K Slonim and Julio Saez-Rodriguez and Lenore J Cowen and Sven Bergmann and Daniel Marbach},
url = {https://www.nature.com/articles/s41592-019-0509-5.pdf},
doi = {10.1038/s41592-019-0509-5},
journal = {Nat. Methods},
volume = {16},
pages = {843–852},
publisher = {Cold Spring Harbor Laboratory},
abstract = {Identification of modules in molecular networks is at the core of many current analysis methods in biomedical research. However, how well different approaches identify disease-relevant modules in different types of gene and protein networks remains poorly understood. We launched the textquotedblleftDisease Module Identification DREAM Challengetextquotedblright, an open competition to comprehensively assess module identification methods across diverse protein-protein interaction, signaling, gene co-expression, homology, and cancer-gene networks. Predicted network modules were tested for association with complex traits and diseases using a unique collection of 180 genome-wide association studies (GWAS). Our critical assessment of 75 contributed module identification methods reveals novel top-performing algorithms, which recover complementary trait-associated modules. We find that most of these modules correspond to core disease-relevant pathways, which often comprise therapeutic targets and correctly prioritize candidate disease genes. This community challenge establishes benchmarks, tools and guidelines for molecular network analysis to study human disease biology (https://synapse.org/modulechallenge).},
keywords = {},
pubstate = {published},
tppubtype = {article}
}